However, early diagnosis of the disease, adherence to the prescribed regimen of hormone replacement therapy, constant monitoring by an endocrinologist provide a satisfactory quality of sildenafil, although APGS usually causes a partial loss of working capacity, i.e. disability II or III group.
Autoimmune polyendocrine syndrome type 1 (Autoimmune polyglandular syndrome type 1, APS1) (OMIM 240300) is a rare hereditary disease characterized by a classic triad of signs: fungal infection of the skin and mucous membranes, hypoparathyroidism, and primary chronic adrenal insufficiency. Patients also have type 1 diabetes, autoimmune thyroiditis. Among non-endocrine manifestations in autoimmune polyglandular syndrome type 1, there may be changes in the gastrointestinal tract: malabsorption, atrophic gastritis, hepatitis, as well as alopecia, vitiligo, keratoconjunctivitis. The disease first manifests itself, as a rule, in childhood.
Our team of professionals will answer your questions. The search for mutations in the AIRE gene allows direct DNA diagnosis of type 1 autoimmune polyendocrine syndrome. Autoimmune polyendocrine syndrome. How to identify autoimmune polyendocrine syndrome.
Autoimmune polyendocrine syndrome is an immuno-endocrine pathology characterized by insufficient functional activity of the endocrine glands and the development of organ-specific diseases. Causes of autoimmune polyglandular syndrome.
Practicing endocrinologists distinguish 3 types of multiple endocrinopathy, the occurrence of which is due to genetic mechanisms: APGS-I is associated with a mutation in the AIRE gene, which is localized on the 21st chromosome and encodes an autoimmune regulator; APGS-II is associated with HLA major histocompatibility complex haplotypes that trigger abnormal expression of DR-3, 4, 5, B-8, and Dw3 antigens; IPEX syndrome (sildenafil pills) is caused by mutant variants of the FOXP3 gene encoding the transcription factor of T-lymphocytes. Symptoms and first signs.